![]() ![]() s resin content 18% asphaltene content 12% and asphaltene-to-resin ratio of 0.75. The average properties of oil required to form entrained w-o are as follows: density 0.97 g/ml viscosity 60,000 mPa. This type of w-o emulsion has a short life span. It has an average water content of 40–50% on the first day of formation and less than 28% 1 week later. Entrained w-o types appear as black viscous liquids. Some water (usually less than about 10%) may be retained by the oil, especially if the oil is viscous. Unstable emulsions rapidly separate into two phases that are water and oil in a short time. s resin content 16% asphaltene content 8% and asphaltene-to-resin ratio of 0.5. The average properties of oil required to form a meso-stable emulsion are as follows: density 0.9 g/ml viscosity 1300 mPa. Meso-stable w-o emulsions are formed of brown or black viscous liquids with an average water content of 60–65% on first day of formation and less than 30% 1 week later and their properties lie between stable and unstable emulsions. s resin content 9% asphaltene content 5% and asphaltene-to-resin ratio of 0.6. The average properties of oil required to form a stable emulsion are as follows: density 0.9 g/ml viscosity 300 mPa. Stable emulsions maintain stability for at least 4 weeks under laboratory conditions. Stable w-o emulsions contain 60 to 80% of water on first day of preparation and are reddish-brown in appearance. Fingas and Fieldhouse discovered that when crude oil is combined with water, four definite w-o types of emulsions were developed: stable, meso-stable, unstable, and entrained emulsions. Ī w-o emulsion has a continuous phase formed of hydrophobic materials (oil) and water (globules) that make up the dispersed phase. Emulsifiers with HLB values 8–14 favor oil-in-water (o-w) emulsions and HLB values 3–6 favor water-in-oil (w-o) emulsions (Fig. The emulsifiers can be described as amphiphilic as they contain both hydrophilic and hydrophobic parts (Fig. It also provides a way of selecting a suitable surfactant for a definite application. A certain type of emulsifier is added to each emulsion in order to stabilize it based on its HLB value. Hydrophilic−lipophilic balance (HLB) (suggested notably by Griffin) represents the oil and water solubility and indicates the class of emulsifiers. Emulsions are added with emulsifiers (surfactants) at the point of interaction (boundary) of the two immiscible liquids as they are thermodynamically unstable. The average dispersed droplet diameter can vary from 100 nm to 100 μm. The s-o-w emulsion technique may become beneficial in near future as it has shown to improve the stability and efficacy of the entrapped active ingredient.Īn emulsion is a subtype of colloid having a biphasic system containing two immiscible liquids, one is the dispersed particles (droplets) which is finely and uniformly distributed as globules throughout the second phase, the continuous phase (surrounding liquid). A summary of the results obtained in each study is presented in this article. This article focuses on the various studies done to investigate the effectiveness of formulations prepared as solid-oil-water emulsions in comparison to conventional water-oil-water emulsions. This dispersion was then mixed with water to form a continuous phase for enhancing the drug absorption. In this method, the active ingredient is encapsulated as a solid and added to an oil phase, which formed a solid-oil dispersion. Thus, a novel “solid-in-oil-in-water” (s-o-w) emulsion system was developed for formulating certain drugs, probiotics, proteins, antibodies, and tannins to overcome these issues. But this method has posed certain problems such as decreased stability, burst release, and low entrapment efficiency. Water (aqueous) phase is commonly used for encapsulating proteins and several other drugs in water-in-oil-in-water (w-o-w) emulsion technique. Various types of emulsions such as water-in-oil (w-o), oil-in-water (o-w), microemulsions, and multiple emulsions are used for delivering certain drugs in the body. An emulsifier is added at the interface of two immiscible liquids to stabilize the thermodynamically unstable emulsion. An emulsion is a biphasic dosage form comprising of dispersed phase containing droplets that are uniformly distributed into a surrounding liquid which forms the continuous phase.
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